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"Five Shades" of Special Stains in Liver Diseases: 

Dr Sampurna Roy  MD






 1) Alpha-1 Antitrypsin Deficiency: PAS stain demonstrates bright pink globules.                


2) Wilson's Disease: Rhodanine Stain demonstrates bright orange to brown granules due copper accumulation in the periportal liver cells. 


3) Hemochromatosis: Perls' Prussian Blue Stain demonstrates coarse dark blue granules of hemosiderin in hepatocytes and Kupffer cells.




4) Cirrhosis : Masson's trichrome stain - The Fibrous tissue (collagen) stain blue and Hepatocytes Stain red. This stain is used to assess degree of fibrosis in cirrhosis.

A) Broad bands of fibrous tissue around small regenerative nodules.

B) A cirrhotic nodule surrounded by fibrous tissue.


5) Alcoholic Liver Disease: Gordon and Sweet's silver stain. The dark brown to black reticulin fibres increased around the hepatocytes.


"Color! What a deep and mysterious language, the language of dreams." Paul Gauguin


What writers can learn from the theory of Work and Energy



Dr  Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)






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