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Gallbladder Pathology Online

Pathology of Sarcomatoid Carcinoma/ Carcinoma of Gallbladder

Dr Sampurna Roy  MD    


Syn: Spindle cell carcinoma

Sarcoma and carcinosarcoma constitute 1.5% of malignant tumours of the gall bladder.

There is female preponderance and a high association with gall stones.

They have a poor prognosis and spread to the liver and  hilar lymph nodes.

Squamous cells may be seen.

Neoplastic glands may contain mucin.

The sarcomatous part is usually spindle celled.

Pleomorphic cells may be present together with areas of heterologous osteosarcoma, chondrosarcoma or rhabdomyosarcoma.  

Pleomorphic spindle cell carcinoma or poorly differentiated adenocarcinoma must be excluded by immunohistochemistry.

Leiomyosarcoma, angiosarcoma, liposarcoma, neurofibrosarcoma, fibrosarcoma and rhabdomyosarcoma have all been reported but are uncommon.


Carcinosarcoma of the gallbladder


Further reading:

Tumours of the gallbladder and extrahepatic bile ducts. In: Hamilton SR, Aaltonen LA, eds. World Health Organization classification of tumors: pathology and genetics of tumours of the digestive system. Lyon, France: IARC,2000 : 204-217.

Primary liposarcoma of gallbladder diagnosed by preoperative imagings: a case report and review of literature.

Primary leiomyosarcoma of the gallbladder. Case report

Epithelioid angiosarcoma of the gallbladder: case report

Gallbladder carcinosarcoma: a case report and literature review

Loss of heterozygosity in clonal evolution with genetic progression and divergence in spindle cell carcinoma of the gallbladder 

Sarcomatoid carcinoma with small cell carcinoma and undifferentiated carcinoma of the gallbladder.

Sarcomatoid carcinoma of the gallbladder with a rhabdoid tumor component 

Carcinosarcoma of the gallbladder

So-called carcinosarcoma of the gallbladder; spindle cell carcinoma of the gallbladder: report of a case

Carcinosarcoma of the gallbladder with chondroid differentiation  

Sarcomatoid carcinoma (carcinosarcoma) of the gallbladder

Carcinosarcoma of the gallbladder. Report of a case and review of the literature





Dr  Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)









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