Spindle cell carcinoma
Sarcoma and carcinosarcoma constitute 1.5% of
malignant tumours of the gall bladder.
There is female preponderance
and a high association with gall stones.
They have a poor prognosis
and spread to the liver and hilar lymph nodes.
Squamous cells may be seen.
Neoplastic glands may contain mucin.
The sarcomatous part is usually spindle celled.
Pleomorphic cells may be present together with
areas of heterologous osteosarcoma,
chondrosarcoma or rhabdomyosarcoma.
cell carcinoma or poorly differentiated adenocarcinoma must be
excluded by immunohistochemistry.
angiosarcoma, liposarcoma, neurofibrosarcoma, fibrosarcoma and
rhabdomyosarcoma have all been reported but are uncommon.
Carcinosarcoma of the gallbladder