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Primary, extranodal, follicular non-Hodgkin lymphoma of the
gallbladder: case report and a review of the literature.Leuk
Lymphoma. 2004 Feb;45(2):381-7.
We report the
first case of isolated primary extranodal non-Hodgkin lymphoma
follicular grade 2 limited to the gallbladder, found in the
laparoscopic cholecystectomy specimen from a 70 year old woman with
symptomatic cholelithiasis. The pericystic duct lymph node, surgical
margins, and other lymph nodes, were not involved with lymphoma.
According to the medical literature in English language, mucosa
associated lymphoid tissue lymphoma (6 cases) is the most frequent
type (38%) of primary gallbladder lymphomas (15 reported cases plus
our case). Our case demonstrates that follicular lymphoma can be
limited to the gallbladder, and confirm that it can occur in an organ
normally devoid of lymphoid tissue.
Primary
non-Hodgkin's lymphoma of the gall bladder.Leuk
Lymphoma. 2000 Dec;40(1-2):123-31.
Primary
non-Hodgkin lymphoma of the gallbladder is a very rare location of
extranodal non-Hodgkin lymphomas. A patient with a primary non-Hodgkin
lymphoma of the gallbladder is reported and in addition, the English
literature is reviewed. Clinical presentation, diagnostic evaluation,
histopathologic findings, treatment modalities and prognosis of
primary gallbladder lymphomas reported up to date are reviewed and
discussed. Our patient was diagnosed as a T-cell lymphoblastic
lymphoma, after cholecystectomy, and had no evidence of disease
elsewhere. She was treated with combination chemotherapy and complete
remission was achieved. She remains free of disease 9 years later.
Review of the literature over a 30-year period revealed only 12 cases
of well-documented primary non-Hodgkin lymphoma involvement of the
gallbladder, including the present case. Patients present clinically
with symptoms and signs indicating either biliary tract pathology or a
gastrointestinal tumor. Diagnostic investigation included ultrasound
of the upper abdomen, computed tomography of the abdomen and pelvis,
oral cholecystography, percutaneous cholangiography and endoscopic
retrograde cholangiopangreatography. Preoperative diagnosis was
established in none of the patients. Treatment modalities included
surgery and postoperative chemotherapy and irradiation. The prognosis
is overall poor and only 2 patients are alive after 1 and 9 years
respectively, the latter being our case. Here we document the first
reported case of a patient with primary T-cell lymphoblastic
non-Hodgkin lymphoma of the gallbladder. Review of the literature
shows the existence of non-Hodgkin lymphoma of the gallbladder, its
rarity and its general dismal prognosis.
Primary
lymphoma of the gallbladder; case report and review of the literature.
Am J
Gastroenterol. 1996 Oct;91(10):2242-4.
The term
extranodal lymphoma refers to lymphoma arising in tissues other than
lymph nodes or major lymphoid organs (1). The GI tract is commonly
involved by lymphoma. Although lymphomas of the liver and the biliary
tree are uncommon, they are well described in the literature. However,
there are only nine cases of primary lymphoma of the gallbladder
reported in the English literature. We report a patient with primary
gallbladder lymphoma diagnosed preoperatively by ultrasound, with
disease confined to the gallbladder on pathology specimens and
radiological examination. His rapid disease progression to diffuse
abdominal involvement in 6 wk points to the importance of a timely
diagnosis. We postulate that delays in making the diagnosis may lead
to the underdiagnosis of primary lymphoma of the gallbladder.
Primary
lymphoma of the gallbladder.Postgrad
Med J.1993;69(813):585-7.
A case of
primary lymphoma of the gallbladder is described which is rare in the
medical literature. A 76 year old man presented with acute
cholecystitis and septicaemia. Investigation showed a lung abscess and
a gallbladder mass. The mass was thought to be an empyema and
cholecystostomy was performed. Biopsy of the gallbladder wall showed
high-grade B cell lymphoma. The patient unfortunately succumbed to
overwhelming septicaemia in the postoperative period. Postmortem
examination confirmed primary lymphoma of the gallbladder without
dissemination.
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