of the gallbladder is defined as an extranodal lymphoma
localized to the gallbladder with or without contiguous
lymph node involvement.
lymphoma is exceptionally rare but the gall bladder may be involved in
patients with systemic lymphoma.
According to the last
World Health Organization (WHO) classification (2016), the spectrum of
lymphomas observed in the gallbladder reflects that of
gastrointestinal tract lymphomas, with predominance of mucosa
associated lymphoid tissue (MALT) type and diffuse large B cells type
It has been suggested
that MALT lymphomas of the gallbladder may occur in the context of
chronic cholecystitis with cholelithiasis or bacterial infection. The
mechanism based on the chronic inflammatory process would be similar
to that described previously in the stomach (Helicobacter
pylori infection) and conjunctiva.
DLBL is the most
common type of primary extranodal NHL. Itís an
aggressive form with a high grade of malignancy, showing a marked
tendency to systemic dissemination.
type is the third most common primary lymphoma of the gallbladder.
The tumour may
present as a large intraluminal mass.
The tumour mass may replace the
gallbladder or there may be a diffuse wall thickening.
the tumour there may be additional findings such as cholelithiasis or
pseudolymphoma, myeloma and angiotropic lymphoma involving gallbladder
have also been reported.