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Gallbladder Pathology Online

Pathology of Lymphoma of the Gallbladder

Dr Sampurna Roy  MD  


Primary lymphoma of the gallbladder is defined as an extranodal lymphoma localized to the gallbladder with or without contiguous lymph node involvement. 

Primary lymphoma is exceptionally rare but the gall bladder may be involved in patients with systemic lymphoma.

According to the last World Health Organization (WHO) classification (2016), the spectrum of lymphomas observed in the gallbladder reflects that of gastrointestinal tract lymphomas, with predominance of mucosa associated lymphoid tissue (MALT) type and diffuse large B cells type (DLBL).

It has been suggested that MALT lymphomas of the gallbladder may occur in the context of chronic cholecystitis with cholelithiasis or bacterial infection. The mechanism based on the chronic inflammatory process would be similar to that described previously in the stomach (Helicobacter pylori infection) and conjunctiva.

DLBL is the most common type of primary extranodal NHL. Itís an aggressive form with a high grade of malignancy, showing a marked tendency to systemic dissemination.

Follicular lymphoma type is the third most common primary lymphoma of the gallbladder.

The tumour may present as a large intraluminal mass.

The tumour mass may replace the gallbladder or there may be a diffuse wall thickening.

Together with the tumour there may be additional findings such as cholelithiasis or sludge.

Cases of pseudolymphoma, myeloma and angiotropic lymphoma involving gallbladder have also been reported.


Further reading:

Primary, extranodal, follicular non-Hodgkin lymphoma of the gallbladder: case report and a review of the literature

Primary non-Hodgkin's lymphoma of the gall bladder.

Primary lymphoma of the gallbladder.

Primary lymphoma of the gallbladder; case report and review of the literature

Primary lymphoma of the gallbladder.

Malignant angioendotheliomatosis (Angiotropic lymphoma) of the gallbladder




Dr  Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)











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