specimens are commonly received in most general histopathology
They are usually
removed for the treatment of chronic cholecystitis and cholelithiasis.
If the composition of the
gall stones needs to be assessed, this can be done by X-ray
Carcinoma of the
gallbladder may be a chance finding in cholecystectomy specimens
removed for apparently non-specific cholecystitis.
diagnosis of carcinoma of the gall bladder or bile ducts is made
clinically the tumour is usually advanced and inoperable.
curative surgery therefore require radical operations with partial hepatectomy.
Most gallbladders are received fixed in formalin, incised but not fully opened
and everted, or (particularly in the early days of laparoscopic
cholecystectomy) in multiple pieces.
examination includes inspection of the mucosa cleaned of all calculous
debris, and examination of any included calculi to identify them as
mixed, pigment, or cholesterol stones.
usually includes three dimensions and wall thickness, the presence or
absence of a cystic lymph node, plastic clips on the neck, and whether
the gall bladder was received opened or unopened, with or without
stones or stone debris.
be made about any anatomical variation, ulcers or tumours.
The presence of
cholesterolosis is easy to recognize macroscopically.
Three sections are
usually taken from routine gallbladder specimens -
1) Neck 2) Body and
Additional sections are
taken from any visible
Sections are taken from cystic
duct and lymph nodes if they appear grossly abnormal or if the
gallbladder contains tumour.
In case of suspected
carcinoma in situ, the entire specimen is embedded ( "swiss roll
Pathol. 2013 Dec;47(6):519-525.