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Gallbladder Pathology Online

Pathology of Cholesterolosis of the Gallbladder

Dr Sampurna Roy MD


Syn: Strawberry Gallbladder


Cholesterolosis (strawberry) gallbladder is the accumulation of cholesterol-laden macrophages in the lamina propria of the gallbladder, and is a common incidental finding at autopsy.

Cholesterolosis per se is symptomless.

Symptoms, if any are generally due to associated gallstones or cholecystitis.

Cholesterolosis is often accompanied by one or more cholesterol stones and is therefore thought to reflect the presence of bile supersaturated with cholesterol.

Cholesterol stones are thought to be derived from the deposits in the mucous membrane.

Grossly, in fresh state the interior of the gallbladder looks something like a strawberry, the yellow specks (submucous aggregations of cholesterol crystals and cholesterol esters) corresponds to the seeds.

Microscopically, the mucosal folds are swollen. Large, foamy lipid laden macrophages, in which a small dark nuclei are present in the villous processes of the mucosa. Initially the lesion involves the tips, later they fill the entire villous process.


Further reading:

Gallbladder cholesterol polyps and cholesterolosis.

[Sonographic image of cholesterolosis of the gallbladder].

Papillary hyperplasia and cholesterolosis of the gallbladder.

Gallbladder polyps, cholesterolosis, adenomyomatosis, and acute acalculous cholecystitis

Cholesterolosis: a physical cause of "functional" disorder.

Fine structure of cholesterolosis in the human gallbladder

Gallbladder cholesterolosis: an aetiological factor in acute pancreatitis of unknown origin

Cholesterosis of the gallbladder and atherogenic dyslipidemia: etiology, pathogenesis, clinical symptoms, diagnosis and treatment  

Biliary calculosis, cholesterosis of the gallbladder xanthogranulematous cholecystitis : clinical-morphological parallels.

Clinical and biochemical aspects of the course of strawberry gallbladder.

"Strawberry" gallbladder: review of the literature and our experience














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