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Gallbladder Pathology Online

Pathology of Undifferentiated Carcinoma of the Gallbladder

Dr Sampurna Roy MD  


Undifferentiated carcinoma has four histologic variants, including spindle and giant cell type, osteoclast-like giant cell type, small cell type, and nodular or lobular type.

The most common and most anaplastic variant is spindle and giant cell type, which has been referred to as sarcomatoid carcinoma.

Undifferentiated carcinoma of the gallbladder tends to form a large mass with central necrosis and exhibits rapid growth with direct invasion into an adjacent organ.

The tumour is highly aggressive and shows progression to lymph node metastasis and peritoneal dissemination.

The prognosis is very poor.

The tumour is often localized to the fundus of the gallbladder.

In some cases no tumour recurrence was evident at the 6 month follow-up.


  Undifferentiated carcinoma of the Gallbladder

Further reading

A patient with undifferentiated carcinoma of gallbladder presenting with hemobilia.

Undifferentiated spindle-cell carcinoma of the gallbladder : an immunohistochemical study.

Albores-Saavedra J, Henson DE, Sobin LH. WHO histological typing of tumors of the gallbladder and extrahepatic bile ducts Berlin, Germany: Springer-Verlag, 1991.

Primary undifferentiated spindle-cell carcinoma of the gallbladder presenting as a liver tumor.

Small-cell undifferentiated carcinoma of neuroendocrine type originating in the gallbladder.

A case of undifferentiated carcinoma of the gallbladder with anomalous arrangement of the pancreaticobiliary ductal system

Unusual malignant epithelial tumors of the gallbladder.

Elevated serum alpha-fetoprotein in a patient with undifferentiated carcinoma of the gallbladder.

Undifferentiated carcinoma of the gallbladder. Report of a case with immunohistochemical findings.

Undifferentiated spindle cell carcinoma of the gallbladder: a clinicopathologic, immunohistochemical, and flow cytometric study of 11 cases.

Undifferentiated carcinoma of the gallbladder. A clinicopathologic, histochemical and immunohistochemical study of 21 patients with a poor prognosis.









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