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Gallbladder Pathology Online

Pathology of Squamous and Adenosquamous Cell Carcinoma of the Gallbladder

Dr Sampurna Roy MD


Squamous and adenosquamous cell carcinomas of the gallbladder are rare.


Microscopic image of adenosquamous carcinoma

The adenosquamous carcinoma contains a mixture of malignant glandular and squamous components.

The pure squamous cell carcinoma constitutes only 1% of all malignant gallbladder tumors and consists of cords, islands, or sheets of malignant squamous cells separated by dense fibrous stroma.

These tumours most likely arise in areas of previous squamous metaplasia, and their histologic features may vary from anaplastic to well-differentiated, keratinizing squamous cell carcinoma.

Their clinical behavior and clinicopathologic characteristics are very different from those of adenocarcinoma.

The tumours characteristically tend to arise from the gallbladder fossa and present rapid and invasive growth, which results in direct invasion into the liver and adjacent organs.

In contrast to their aggressive tendency and advanced stage, they usually do not present lymph node metastasis or peritoneal seeding.

Liver metastases are more frequently seen, however, than with the adenocarcinoma.


Further reading:

Adenosquamous and squamous carcinoma of the gallbladder

Adenosquamous carcinoma of the gallbladder warrants resection only if curative resection is feasible.

Adenosquamous carcinoma of the gallbladder with spindle cell features. A light microscopic and immunocytochemical study of the case.

Stromal osteoclast-like giant cells in an adenosquamous carcinoma of the gallbladder

Adenosquamous/squamous cell carcinoma of the gallbladder

Adenosquamous carcinoma of the gallbladder.

Adenosquamous carcinoma of the gall-bladder with gastric foveolar-type epithelium

Hepatopancreatoduodenectomy for squamous and adenoaquamous carcinoma of the gallbladder.

Adenosquamous carcinoma of the gallbladder: a clinicopathological, immunohistochemical and flow-cytometric study of twenty cases.

Albores-Saavedra J, Henson DE, Sobin LH. WHO histological typing of tumors of the gallbladder and extrahepatic bile ducts Berlin, Germany: Springer-Verlag, 1991.














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