small (oat) cell carcinoma has been found in various sites
including the gallbladder.
cell carcinomas of the gallbladder are rare and highly
It is more
common in women and usually associated with cholelithiasis.
characteristic morphologic features of small cell carcinoma
of the gallbladder include a large mass at presentation, extensive
necrosis, and a propensity for submucosal growth.
histologically identical to small cell carcinomas of the lung
and gastrointestinal tract.
Small cell carcinoma of the
syndromes may be associated with small cell carcinoma of
the gallbladder, and Cushing syndrome has been reported in
association with a corticotropin-secreting apudoma of the
tends to metastasize in the early stage, which results in
death shortly after diagnosis.
Although small cell
carcinoma of the gallbladder is a distinct histologic and clinical entity, it has many clinical
characteristics similar to adenocarcinoma of the gallbladder including
comparable natural history and tendency for locoregional spread.
therapy, especially the combination of surgery and chemotherapy, may