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Signet-Ring Cell Carcinoma of Gall Bladder

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Visit: Gall Bladder Pathology Online 
Carcinoma of Gall Bladder ; Adenocarcinoma of Gall Bladder ; Papillary Adenocarcinoma of Gall Bladder ; Intestinal-type Adenocarcinoma of Gall Bladder ; Mucinous Adenocarcinoma of Gall Bladder.

Signet-ring cell carcinoma  contains cells with intracytoplasmic mucin, which displaces the nuclei toward the periphery.

The characteristic feature of the tumour is spreading laterally through the lamina propria.

When the tumour is confined to the surface epithelium or invaginations (Rokitansky-Aschoff sinuses), it may be regarded as an in situ carcinoma.

When stromal invasion occurs, the cells grow in cords, nests, and sheets and may form incomplete glandular structures within a mucoid stroma.

Infiltrative submucosal growth can be a prominent feature of signet-ring cell tumours and may occasionally resemble linitis plastica of the stomach.

                   

Abstracts:

Albores-Saavedra J, Henson DE, Sobin LH. WHO histological typing of tumors of the gallbladder and extrahepatic bile ducts Berlin, Germany: Springer-Verlag, 1991.

Albores-Saavedra J, Henson DE. Tumors of the gallbladder and extrahepatic bile ducts: atlas of tumor pathology Fasc 22, ser 2. Washington, DC: Armed Forces Institute of Pathology, 1986.

Signet-ring cell carcinoma of the gallbladder: a case report.Adv Ther. 2008 May;25(5):520-3.

Gallbladder cancers are recognised common tumours of the gastrointestinal system. Histologically, almost all of them are adenocarcinomas. Previously, only two cases of signet-ring cell carcinoma of the gallbladder have been published, and little is known about the disease. Here, we present the case of a 76-year-old man with signet cell carcinoma of the gallbladder. Despite radical surgery, followed by 5-fluorouracil infusion chemotherapy, our patient died within 3 months. Advanced information may help to improve the prognosis of this tumour.

Signet-ring cell carcinoma of the gallbladder with skin metastases. Australas J Dermatol. 2007 Aug; 48(3):187-9.

Cutaneous metastasis from gallbladder cancer is extremely rare. We present a case of signet-ring cell carcinoma of the gallbladder metastatic to the skin in a 38-year-old man. The skin nodules on the face, scalp and perianal area occurred approximately 1 year after the resection of the neoplasm. Skin metastases from gastrointestinal cancers are usually detected around surgical scars or on the abdominal wall, especially in the periumbilical region, and rarely present at other sites. Multiple imaging studies revealed the presence of metastatic bony involvement in the spine and left orbit. Visceral metastases have not been demonstrated in our patient in 20 months of follow up since the initial diagnosis of gallbladder cancer was made. We also briefly discuss other primary and metastatic skin tumours with signet-ring cell morphology.

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