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Gallbladder Pathology Online

Pathology of Signet-Ring Cell Carcinoma of the Gallbladder

Dr Sampurna Roy MD


Signet-ring cell carcinoma of the gallbladder contains cells with intracytoplasmic mucin, which displaces the nuclei toward the periphery.


1) Low power : Signet-ring cell carcinoma of the gallbladder.

2) Cells with intracytoplasmic mucin. The nuclei is displaced to the periphery.

The characteristic feature of the tumour is spreading  laterally through the lamina propria.

When the tumour is confined to the surface epithelium or invaginations (Rokitansky-Aschoff sinuses), it may be regarded as an in-situ carcinoma.

When stromal invasion occurs, the cells grow in cords,  nests, and sheets and may form incomplete glandular structures within a mucoid stroma.

Infiltrative submucosal growth can be a prominent feature of signet-ring cell tumours and may occasionally resemble linitis plastica of the stomach.


Further reading:

Carcinoma of the gallbladder. Histologic types, stage of disease, grade, and survival rates.

Signet Ring Cell Carcinoma of the Gallbladder with Skin Metastasis: A Case Report -with images

Primary signet ring cell carcinoma of gall bladder: a case report

Signet-ring cell carcinoma of the gallbladder: a case report.

Signet Ring Cell Carcinoma of the Gallbladder with Skin metastases

Primary cutaneous signet ring cell carcinoma expressing cytokeratin 20 immunoreactivity.

Albores-Saavedra J, Henson DE, Sobin LH. WHO histological typing of tumors of the gallbladder and extrahepatic bile ducts Berlin, Germany: Springer-Verlag, 1991.

Albores-Saavedra J, Henson DE. Tumors of the gallbladder and extrahepatic bile ducts: atlas of tumor pathology Fasc 22, ser 2. Washington, DC: Armed Forces Institute of Pathology, 1986.  









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