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Abstracts:
Albores-Saavedra J,
Henson DE, Sobin LH. WHO histological typing of tumors of the
gallbladder and extrahepatic bile ducts Berlin, Germany: Springer-Verlag,
1991.
Mucin-producing carcinoma of the gallbladder: imaging demonstration in
four cases.J
Comput Assist Tomogr. 2003 Mar-Apr;27(2):150-4.
We report four
cases of mucin-producing carcinoma of the gallbladder (three papillary
adenocarcinomas and one mucinous carcinoma), with an emphasis on
imaging features. Our findings suggest that when a papillary
protrusion or thickened wall, including cystic areas and/or
calcifications, is seen radiologically in the enlarged gallbladder,
mucin-producing carcinoma of the gallbladder should be included in the
differential diagnosis.
Well-differentiated adenocarcinoma of the gallbladder with
intratumoral cystic components due to abundant mucin production: a
mimicker of adenomyomatosis.Eur
Radiol. 2005 Feb;15(2):229-33. Epub 2004 Nov 3.
The prevalence
and etiology of the cystic components within gallbladder carcinomas as
seen on MR images were evaluated. A retrospective review of MR images
was performed for 35 proven gallbladder carcinomas in search of
radiologically detectable intratumoral cystic components. The
pathologic specimens were meticulously reviewed to determine the
etiology. MR images of 31 adenomyomatoses were also reviewed for
comparison to clarify the difference in MR features between these two
entities. Three cases out of 35 proven gallbladder carcinomas were
found to have intratumoral cystic components. They were all
well-differentiated adenocarcinomas, and the cystic components
consisted of dilated neoplastic glands filled with abundant mucin
pool. Adenomyomatosis tended to have more and rounded cystic
components (Rokitansky-Aschoff sinuses) lined in a linear fashion and
were flat-elevated in shape, smaller in size and had a regular
surface, as compared to the three carcinomas. Although rare,
radiologists need to be aware that well-differentiated gallbladder
carcinoma with mucin production can have cystic components, which may
mimic adenomyomatosis. Careful interpretation of MR images may provide
useful information in the differentiation of these two entities.
Case of mucinous adenocarcinoma with porcelain gallbladder.J
Gastroenterol Hepatol. 2003 Aug;18(8):995-8.
Histologically,
the majority of gallbladder cancers are adenocarcinomas. Among the
adenocarcinomas, the mucinous adenocarcinoma is relatively uncommon.
Porcelain gallbladder is a rare finding and the risk of gallbladder
cancer is significantly increased in porcelain gallbladder. We
describe a rare case of mucinous adenocarcinoma with porcelain
gallbladder. A 46-year-old man was admitted to Chonnam National
University Hospital with a 2-week history of right upper quadrant
pain. Three and 2 years previously, he had two episodes of
cholecystitis with gallstones. An abdominal computed tomography
revealed a contracted gallbladder with circumferential mural
calcification, and the possibility of gallbladder cancer and porcelain
gallbladder were considered. At laparotomy, cholecystectomy, liver
wedge resection, and radical lymph node dissection were performed. The
resected gallbladder showed thickened wall, luminal narrowing and
mucosal irregularity. A histological examination of the resected
gallbladder showed a mucinous adenocarcinoma composed of poorly
differentiated glandular cells with mucin lakes. Porcelain gallbladder
may be an end result of a chronic inflammatory reaction, and this
change is associated with the development of gallbladder cancer.
Prediction of prognosis in gallbladder carcinoma by mucin and p53
immunohistochemistry.Dig
Dis Sci. 2005 Aug;50(8):1410-3.
Mucin core
proteins are known to be present in various organs and are
specifically expressed with carcinogenesis and closely associated with
the prognoses of various malignant tumors in the digestive tract such
as colorectal cancer. The present study evaluated correlations between
mucin and p53 expression and prognosis of gallbladder cancer using
surgically resected tissue specimens from 26 patients with gallbladder
carcinoma surgically treated at our hospital. Immunohistochemical
staining was performed using MUC 1, MUC2, and p53 monoclonal antibody.
The level of antigen expression in the lesion was classified into four
stages: none(-), slight(+), moderate (++), and severe (+ + +).
According to the UICC classification, histopathological grading,
levels of T, N, and M factors, and tumor stages were compared with
regard to the correlations with mucin and p53 expression. All cases
were classified into two groups according to the results of mucin
immunohistochemistry: group A (MUC1, > or = ++; and MUC2, < or = +)
and group B (MUC1, < ++; or MUC2, > +). Postoperative survival periods
were compared between the two groups and p53-positive and -negative
groups. Neither histological grading nor T factor correlated with
mucin or p53 expression, respectively. Moreover, neither N factor nor
M factor correlated with mucin or p53 expression. Furthermore, stage
grouping did not correlate with mucin or p53 expression. However, when
the correlation between the postoperative survival period and mucin
expression was evaluated, the mean postoperative surgical period was
significantly shorter in Group A than in Group B (1.02 years in Group
A vs 2.92 years in Group B; P = 0.016). There was no relationship
between postoperative survival period and p53 positivity. Mucin
expression was independent of various tumor growth factors and clearly
reflected the prognosis of gallbladder cancer. Because the relative
malignancy of gallbladder cancer could be evaluated by examining the
level of glycoprotein expression in tumor tissue, mucin could be a
more important marker than p53 for predicting prognosis in gallbladder
carcinoma using surgically resected tissue specimens.
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