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Gallbladder Pathology Online

Pathology of  Intestinal-type Adenocarcinoma of Gallbladder

Dr Sampurna Roy MD    


The intestinal type adenocarcinoma resembles intestinal epithelium and is believed to be a variant of well-differentiated adenocarcinoma.

This category has two subtypes, which are characterized by the appearance of the intestinal glands:

(a) those lined chiefly by goblet cells  and

(b) those resembling the glands of colonic adenocarcinoma.

Often, these subtypes are mixed within the same tumor and may also contain foci of ordinary well-differentiated adenocarcinoma.

Microscopic features:


The glands are predominantly lined by columnar cells with pseudostratified oval or elongated nuclei.

The cells show varying degrees of atypia and a variable number of mitotic figures.

In some carcinomas, goblet cells are interspersed with the columnar cells.

Rarely, Paneth cells and endocrine cells are also present.

Carcinomas arising from adenomas have a better prognosis than adenocarcinomas not associated with adenomas.


Further reading:

Intestinal-type adenocarcinoma of the gallbladder:  A Clinicopathologic and Immunocytochemical Study of Seven Cases.

Histopathological and immunophenotypical features of intestinal-type adenocarcinoma of the gallbladder and its precursors.

Differentiation towards gastric foveolar mucopeptic and intestinal goblet cells in gallbladder adenocarcinoma

Carcinoma involving the gallbladder - Diagnostic Pathology

WHO Classification of Tumours of the Digestive System., 4th Edition, International Agency for Research on Cancer, Lyon 2010





Dr  Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)











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