type adenocarcinoma resembles intestinal epithelium and is
believed to be a variant of well-differentiated adenocarcinoma.
This category has
two subtypes, which are characterized by the appearance of
the intestinal glands:
lined chiefly by goblet cells and
resembling the glands of colonic adenocarcinoma.
subtypes are mixed within the same tumor and may also
contain foci of ordinary well-differentiated adenocarcinoma.
The glands are predominantly lined by columnar cells with
pseudostratified oval or elongated nuclei.
The cells show varying
degrees of atypia and a variable number of mitotic figures.
carcinomas, goblet cells are interspersed with the columnar cells.
Rarely, Paneth cells and endocrine cells are also present.
Carcinomas arising from adenomas have a better prognosis than
adenocarcinomas not associated with adenomas.