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Abstracts:
Differentiation towards
gastric foveolar, mucopeptic and intestinal goblet cells in
gallbladder adenocarcinomas.
Histopathology. 1996 Nov;29(5):443-8.
Cellular
differentiation in 22 surgically removed adenocarcinomas of the
gallbladder was immunohistochemically studied with antibodies specific
to mucins of gastric foveolar cells (M1), (pseudo)pyloric cells (M2)
and intestinal goblet cells (M3), and also with antibodies against
pepsinogen II and chromogranin A. More than 70% of tumours (16 of 22
cases) displayed gastric- and/or intestinal-type differentiation, most
of which (12 of 16 cases) showed both types of differentiation. Two
tumours showed an organoid growth pattern similar to the normal
gastric mucosa. The presence of endocrine cells positive for
chromogranin A was closely related to that of gastric- and/or
intestinal-type cells. The present findings clearly indicate the
multidirectional differentiation of gallbladder adenocarcinomas and
suggest that most gallbladder adenocarcinomas develop and progress
under induction of gastric and intestinal differentiation.
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