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Gallbladder Pathology Online

Pathology of Eosinophilic Cholecystitis

Dr Sampurna Roy  MD 


Eosinophilic cholecystitis is a rare form of cholecystitis. It was described for the first time by Albot in 1949.

Histologically, it is characterized by a dense, transmural leukocyte infiltrate composed of more than 90% eosinophils.

The etiology remains obscure, although it had been associated with  hypereosinophilic syndromes, eosinophilic gastroenteritis, cholelithiasis, and acalculous cholecystitis.  Eosinophilic cholecystitis has been linked to parasitic infections like Echinococcus, Clonorchis sinensis or Ascaris lumbricoides.

When there is an excess of eosinophils, one should be aware of worms, antibiotic therapy, allergy or eosinophilic granulomatous arteritis such as Eosinophilic granulomatosis with polyangiitis.

The clinical presentation is equal to acute cholecystitis and the diagnosis is based on the presence of an eosinophilic infiltrate >90% in the histologic study of the gallbladder.


Further reading:

Eosinophilic Cholecystitis, with a Review of the Literature.

Case 57: Eosinophilic Cholangiopathy.

Eosinophilic Cholecystitis: A Case Report: Internet Journal of Surgery.(

Eosinophilic cholecystitis as a rare manifestation of visceral larva migrans

Eosinophilic cholecystitis along with pericarditis caused by Ascaris lumbricoides: a case report.

Eosinophilic cholecystitis, with a review of the literature.

Clonorchiasis-associated perforated eosinophilic cholecystitis

Eosinophilic cholecystitis as a possible late manifestation of the eosinophilia-myalgia syndrome.

Eosinophilic cholecystitis: an infrequent cause of cholecystectomy.

Deposits of eosinophil granule proteins in eosinophilic cholecystitis and eosinophilic colitis associated with hypereosinophilic syndrome  

Eosinophilic cholecystitis associated with rupture of hepatic hydatid cyst of the bile ducts

Eosinophilic and lymphoeosinophilic cholecystitis.

Acute eosinophilic cholecystitis in association with hepatic echinococcosis

Eosinophilic cholecystitis.










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