blog counter
    

 

      Pathology-India.com

 Eosinophilic Cholecystitis

 
 

                    

Eosinophilic cholecystitis is a rare form of cholecystitis.

Histologically, it is characterized by a dense, transmural leukocyte  infiltrate composed of more than 90% eosinophils.

The etiology remains obscure, although it had been associated with   hypereosinophilic syndromes, eosinophilic gastroenteritis, cholelithiasis, and acalculous cholecystitis. 

When there is an excess of eosinophils, one should be aware of worms, antibiotic therapy, allergy or eosinophilic granulomatous arteritis such as Churg-Strauss syndrome.

Visit: Acute cholecystitis ; Acalculous cholecystitis ; Emphysematous cholecystitis ; Churg-Strauss Syndrome (allergic granulomatosis) ; Eosinophilic Pancreatitis.

                     

Eosinophilic Cholecystitis, with a Review of the Literature. Annals of Clinical & Laboratory Science 37:182-185 (2007).

Case 57: Eosinophilic Cholangiopathy.Radiology 2003;227:107-112.)

Eosinophilic Cholecystitis: A Case Report: Internet Journal of Surgery.(ispub.com)

Eosinophilic cholecystitis as a rare manifestation of visceral larva migrans.World J Gastroenterol. 2007 Dec 7;13(45):6119.

Eosinophilic cholecystitis is an infrequent form of cholecystitis. The etiology of eosinophilic cholecystitis is still obscure, and it is sometimes accompanied with several complications, but a simultaneous onset with pericarditis is very rare. We would like to make an alternative interpretation of our recent report "Kaji K, Yoshiji H, Yoshikawa M, Yamazaki M, Ikenaka Y, Noguchi R, Sawai M, Ishikawa M, Mashitani T, Kitade M, Kawaratani H, Uemura M, Yamao J, Fujimoto M, Mitoro A, Toyohara M, Yoshida M, Fukui H. Eosinophilic cholecystitis along with pericarditis caused by Ascaris lumbricoides.

Eosinophilic cholecystitis along with pericarditis caused by Ascaris lumbricoides: a case report.World J Gastroenterol. 2007;13(27):3760-2.

Although the etiology of eosinophilic cholecystitis is still obscure, the postulated causes include allergies, parasites, hypereosinophilic syndrome, and eosinophilic gastroenteritis. It is sometimes accompanied by several complications, but a simultaneous onset with pericarditis is very rare. A 28-year-old woman complained of acute right hypocondrial pain and dyspnea associated with systemic eruption. Several imaging modalities revealed acute cholecystitis and pericarditis with massive pericardial effusion. A marked peripheral blood eosinophilia was observed, and the eruption was diagnosed as urticaria. Her serum had a high titer of antibody against Ascaris lumbricoides. Treatment with albendazole drastically improved all clinical manifestations along with normalization of the imaging features and eosinophilia. We report herein a rare case of simultaneous onset of acute cholecystitis and pericarditis associated with a marked eosinophilia caused by parasitic infection.

Eosinophilic cholecystitis, with a review of the literature.Ann Clin Lab Sci. 2007 Spring;37(2):182-5.

Eosinophilic cholecystitis (EC) is a rare entity that presents in a manner comparable to acute cholecystitis. The diagnosis is based on classical symptoms of cholecystitis with the presence of >90% eosinophilic infiltration within the gallbladder. We report the case of a 29-yr-old man who presented with unremitting right upper quadrant pain, chills, and loss of appetite. After confirmation of the diagnosis with ultrasound and hepatobiliary scan (HIDA), a cholecystectomy was performed. Pathologic examination of the excised gallbladder demonstrated submucosal infiltration with eosinophils, consistent with EC. Peripheral eosinophilia was not observed; the subject's blood eosinophil count did not exceed 3% during the period of observation. The patient was discharged with no further symptoms. Cases of EC have been infrequently reported since its original description in 1949. EC has been reported alone or in combination with manifestations such as eosinophilic cholangitis, hypereosinophilic syndromes (HES), and parasitic infestations. The patient described herein gave no indications of such previously suggested causes of EC. This report illustrates an authentic case of idiopathic EC.

Clonorchiasis-associated perforated eosinophilic cholecystitis.Am J Trop Med Hyg. 2007 Feb;76(2):396-8.

Clonorchiasis, a disease caused by infection with Clonorchis sinensis, is endemic in the Far East. Cholelithiasis, pyogenic cholangitis, cholecystitis, and biliary tract obstruction are common complications of chronic infection. Although cholecystitis caused by clonorchiasis is common, it is rarely reported as resulting from eosinophilic infiltration. We report a rare case of clonorchiasis-associated perforated eosinophilic cholecystitis and review the relevant literature.

Eosinophilic cholecystitis as a possible late manifestation of the eosinophilia-myalgia syndrome.Clin Rheumatol. 2000;19(6):470-2.

We describe a case of acute acalculous cholecystitis occurring in a 43-year-old woman with a history of the eosinophilia-myalgia syndrome, associated with the ingestion of 1-tryptophan. The patient underwent a laparoscopic cholecystectomy and subsequent histological examination of the gallbladder revealed an infiltrate predominantly of eosinophils, suggesting a possible relationship to the underlying condition. This may represent a late complication of the eosinophilia-myalgia syndrome--such an association has not previously been reported in the literature. The gastrointestinal and hepatic complications of this syndrome are discussed.

Eosinophilic cholecystitis: an infrequent cause of cholecystectomy. Gastroenterol Hepatol. 1997 Jan;20(1):21-3.

Eosinophilic cholecystitis is a rare form of cholecystitis. Histologically, it is characterized by a dense, transmural leukocyte infiltrate composed of more than 90% eosinophils. The etiology remains obscure, although it had been associated with allergies, parasites, hypereosinophilic syndromes, eosinophilic gastroenteritis, cholelithiasis, and acalculous cholecystitis. Here we report an eosinophilic cholecystitis gallstone-associated case, the only one with this histopathologic diagnosis among 5,537 cholecystectomies made in our hospital in the last years.

Deposits of eosinophil granule proteins in eosinophilic cholecystitis and eosinophilic colitis associated with hypereosinophilic syndrome.Dig Dis Sci. 1996 Feb;41(2):282-8.

A case of hypereosinophilic syndrome with eosinophilic colitis, eosinophilic cholecystitis, and increased serum levels of interleukin-5 (IL-5) and soluble interleukin-2 receptor (sIL-2R) is reported. Immunohistochemical studies of cholecystectomy and colon biopsy specimens with monoclonal antibodies, which are specific for activated eosinophils, secreted eosinophil cationic protein (ECP) and for major basic protein (MBP), demonstrated the presence of numerous activated eosinophils, secretion of ECP, and deposition of MBP in areas of tissue damage. These findings suggest that in eosinophilic cholecystitis and eosinophilic colitis, activated eosinophils infiltrate and degranulate in each tissue, releasing eosinophil granule proteins that produce tissue damage.

Eosinophilic cholecystitis associated with rupture of hepatic hydatid cyst of the bile ducts. Rev Esp Enferm Dig. 1995 Dec;87(12):899-902.

Eosinophilic cholecystitis is a rare finding characterized by an inflammatory infiltrate composed primarily of eosinophils. We report a case of eosinophilic cholecystitis associated with hepatic hydatic cyst ruptured into the biliary tract. The release of hydatid cyst content into the biliary tract may have induced a hypersensitivity reaction with numerous eosinophils in the gallbladder wall.

Eosinophilic and lymphoeosinophilic cholecystitis.Am J Surg Pathol. 1993 May;17(5):497-501.

Eosinophilic cholecystitis (EC) is an infrequent and poorly understood inflammatory condition of the gallbladder. First described in 1949, EC may be defined as an inflammatory condition of the gallbladder in which the inflammatory infiltrate is composed predominately of eosinophils so that their presence clearly overshadows the presence of any other inflammatory cell component. In the few reports that describe EC, it has been described in association with acalculous cholecystitis, with subacute cholecystitis lasting 2 to 3 weeks and with several forms of drug therapy. This retrospective clinicopathologic study reviewed the histopathologic features of 217 consecutive cholecystectomy specimens with special clinical reference to the timing of gallbladder removal after symptoms, previous drug therapy, systemic infection, and the presence of cholelithiasis. Pathologically, 48 of these cases (22.2%) contained eosinophils to some degree. Eosinophilic cholecystitis was diagnosed in 14 (6.4%) of the specimens, and another 14 (6.4%) specimens demonstrated substantial numbers of eosinophils but also had other types of inflammatory cells in abundance, including neutrophils and lymphocytes. Of the eight patients with acalculous cholecystitis, six had substantial eosinophils in their gallbladders, whereas the other two patients had no eosinophils. In this study, EC was more prevalent than in other reported series, and it did not show any association with the timing of gallbladder removal after initial symptoms, drug therapy, or other preexisting medical conditions. Eosinophilic cholecystitis is more common than previously recognized and probably represents a subgroup of patients with a unique or hypersensitivity type of inflammatory response to altered bile. Large numbers of eosinophils in the inflammatory infiltrate occurred three times more commonly in patients with acalculous cholecystitis than in patients with cholelithiasis.

Acute eosinophilic cholecystitis in association with hepatic echinococcosis. Gastroenterology. 1979 Oct;77(4 Pt 1):758-60.

A patient with acute eosinophilic cholecystitis is presented. This was in association with hepatic hydatid disease and was the presenting feature of that disease.

January 2008 
Surgical-Pathology.com

Histopathology-India.net

Pathology-India.com

Pancreatic Pathology Online

Paediatric Pathology Online

Paraganglioma-Online

Endocrine Pathology Online

Eye Pathology Online

Ear Pathology Online

Cardiac Path Online

Lung Tumour-Online

Mesothelioma-Online

Pulmonary Pathology Online

Nutritional Pathology Online

Environmental Pathology Online

Pathology Quiz Online

Dermpath-India

GI Path Online

Soft Tissue Pathology

Case Index

Infectious Disease Online; INDEX: A-D ; INDEX: E-L ; INDEX: M-P INDEX: Q-Z ; FUNGAL DISEASE ; VIRAL DISEASE.

Eosinophilic cholecystitis, appendiceal inflammation, pericarditis, and cephalosporin-associated eosinophilia. Dig Dis Sci. 1994 Feb;39(2):418-22.

A patient with eosinophilic cholecystitis and accompanying eosinophilic appendiceal inflammation, eosinophilic pericarditis, and peripheral eosinophilia is described. Review of the nine previously reported cases of eosinophilic cholecystitis suggests that this is the first case with closely associated eosinophilic appendiceal inflammation and pericarditis as manifestations of a systemic hypereosinophilic syndrome. The possible etiologic role of cephalosporin hypersensitivity is discussed.

Eosinophilic cholecystitis. Am J Gastroenterol. 1976 Oct;66(4):349-52.

A somewhat obese, 40-year old female presented with a classic history of gallbladder disease and a peripheral eosinophilia of 14% without an allergic history. A nonvisualizing oral cholecystogram was followed by an uneventful cholecystectomy. Pathological examination revealed a calculus in the cystic duct and a pure transmural eosinophilic infiltrate of the gallbladder wall. Postoperatively the peripheral eosinophilia returned to normal. Biopsies of the small bowel one year later showed focal mucosal eosinophilia when the patient had recurrent abdominal pain, diarrhea and peripheral eosinophilia. Eosinophilic cholecystitis may represent a descrete entity in search of an etiology or involvement of the biliary tract by eosinophilic gastroenteritis.