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Condyloma acuminatum associated with syringocystadenoma papilliferum.Am
J Dermatopathol. 1994 Dec;16(6):628-30.
A 70-year-old man
presented with a keratotic lesion of the right buttock. Histologic
examination revealed an endophytic cystic and papillary lesion of the
dermis. The papillae were lined by two layers of cuboidal epithelial
cells with a dense plasmacytic infiltrate of the stroma, consistent
with syringocystadenoma papilliferum (SCAP). The overlying epidermis
showed acanthosis, papillomatosis, and hyperkeratosis. There were
multiple foci of prominent koilocytotic atypia. In situ DNA probes for
HPV type 6/11 were positive in many epidermal nuclei. The concurrent
occurrence of SCAP and CA may be coincidental; however, the occurrence
of CA may be related to the environment at the surface of the SCAP.
Syringocystadenoma papilliferum often occurs in association with nevus
sebaceus (NS), but it has also been reported from most body sites.
When it is not seen in association with NS, the epidermis overlying
SCAP may be hyperkeratotic or verrucous. The verrucous changes in our
case had features of condyloma acuminatum (CA), which were confirmed
by in situ DNA probes.
Syringocystadenocarcinoma papilliferum: case report and
immunohistochemical comparison with its benign counterpart.J
Am Acad Dermatol. 2001 Nov;45 (5): 755-9.
Syringocystadenocarcinoma papilliferum (SCACP) is the malignant
counterpart of syringocystadenoma papilliferum (SCAP), although only a
few cases have been reported in the literature and its clinical and
histologic characteristics are not well known. We report a case of
SCACP that started as an enlarging nodule over 10 years in the
perianal area of a 61-year-old man. Macroscopically, the lesion was a
black exophytic tumor, 6 cm in diameter, with a granular surface.
Histologically, it was an in situ adenocarcinoma, showing cytologic
atypia and pagetoid spread in the surrounding epithelia, although the
clinicopathologic features were distinct from extramammary Paget's
disease. The tumor lacked the typical double-layered pattern of SCAP
but had some similar histopathologic features to SCAP. Decapitation
secretion was apparent and there was positive immunoreactivity to
epithelial membrane antigen and human milk fat globules subclass 2.
SCACP is a rare cutaneous tumor but nevertheless represents a specific
dermato- pathologic entity. |
