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Sebaceous carcinoma, basal cell carcinoma, trichoadenoma,
trichoblastoma, and syringocystadenoma papilliferum arising within a
nevus sebaceus.
Dermatol Surg. 2004 Dec;30(12 Pt 2):1546-9.
BACKGROUND: Nevus
sebaceus has a well-documented potential to develop a wide variety of
neoplasms of both epidermal and adnexal origins. It is highly unusual
for more than three tumors to arise simultaneously within a single
nevus sebaceus. Sebaceous carcinoma arising within a nevus sebaceus is
a rare occurrence. OBJECTIVE: The objective was to report the case of
a patient with a nevus sebaceus that simultaneously developed five
distinct neoplasms of epidermal and various adnexal origins and to
report the fourth case of sebaceous carcinoma arising within a nevus
sebaceus. METHODS: A 45-year-old woman presented with a nevus sebaceus
that contained five separate neoplasms, including sebaceous carcinoma,
basal cell carcinoma, trichoadenoma, trichoblastoma, and
syringocystadenoma papilliferum. RESULTS: Complete excision of the
nevus sebaceus and the five tumors was performed. Systemic work-up
showed no evidence of metastatic disease or association with Muir-Torre
syndrome. CONCLUSION: This case report highlights the diverse
neoplastic potential of nevus sebaceus and demonstrates the capacity
of this hamartoma to develop aggressive tumors, such as sebaceous
carcinoma. Prophylactic excision or at least close clinical
surveillance for sudden development of new growths is warranted in all
cases of nevus sebaceus.
Hidradenoma papilliferum with mixed histopathologic features of
syringocystadenoma papilliferum and anogenital mammary-like glands.
J Cutan Pathol. 2004 Sep;31(8):561-4.
A case of
hidradenoma papilliferum with mixed features of syringocystadenoma
papilliferum (SCAP) and anogenital mammary-like glands is reported. A
single, fresh red-colored nodule developed in the sulcus between the
labia majora and minora of a 49-year-old Japanese woman.
Histopathologically, the tumor showed epithelial lining with apocrine
secretion and slight connective tissues characteristics. Our case was
unique because, like SCAP, the tumor was connected to the epidermis
and cystic invaginations extended downward into the deep dermis. In
addition, beneath the tumor, tubular structures that resembled normal
mammary tissue were present in the subcutaneous fatty tissue. In this
study, it has been suggested that this tumor might have been developed
from these mammary-like glands. |
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Syringocystadenoma
Papilliferum
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Dermpath-India
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Ductal carcinoma arising from a syringocystadenoma papilliferum in a
nevus sebaceus of Jadassohn.Am
J Dermatopathol. 2003 Dec;25(6):490-3.
We present an
example of ductal carcinoma connected to a syringocystadenoma
papilliferum situated in a nevus sebaceus of Jadassohn on the scalp
of a 22-year-old woman. The ductal carcinoma involved the entire
thickness of the dermis and extended to the subcutaneous fat.
Because syringocystadenoma papilliferum is considered a hamartoma
with apocrine differentiation, the ductal carcinoma here described
was interpreted as an apocrine ductal carcinoma.
Syringocystadenocarcinoma papilliferum is an exceedingly rare
neoplasm, most examples of which seem to have arisen in its benign
counterpart, syringocystadenoma papilliferum. From a histopathologic
point of view, syringocystadenocarcinoma papilliferum usually shows
a papillary configuration similar to that of syringocystadenoma
papilliferum. In contrast, the case here described a ductal
carcinoma superficially connected to a syringocystadenoma
papilliferum, but mostly composed of small ductal structures
embedded in a desmoplastic stroma and involving the full thickness
of the dermis. We review the literature about the malignant
neoplasms arising in the nevus sebaceus of Jadassohn.
A
case of syringocystadenocarcinoma papilliferum in situ occurring
partially in syringocystadenoma papilliferum.J
Dermatol. 2003 Feb;30(2):146-50.
We report a
case of syringocystadenocarcinoma papilliferum in situ associated
with syringocystadenoma papilliferum. The patient was a 64-year-old
man with a red tumor that arose on top of his head two years before
he consulted our department. The histological findings revealed a
papillomatous growth on the epidermis forming several invaginations.
Numerous papillary projections, lined by a two-layered epithelium
with a benign appearance and decapitations on the luminal surface of
the cells, extended into the lumens of the invaginations. Some
projections showed a disorderly arrangement of multilayered cells
with atypical nuclei. No differences between findings in the
syringocystadenocarcinoma papilliferum in situ and those in the
syringocystadenoma papilliferum were observed histochemically (PAS)
or immunohistochemically (cytokeratin, CEA, CA 19-9, S-100, gross
cystic disease fluid protein, lysozyme and Leu M1). |
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August 2009
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