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Multiple lymphomatous
polyposis of the gastrointestinal tract.Cesk
Patol. 1997 Nov;33(4):123-6.
We studied three
patients in whom histology revealed multiple lymphomatous polyposis of
the gastrointestinal tract. It is a distinctive type of primary
gastrointestinal lymphoma characterized by polypoid accumulations of
lymphoma tissue involving long segments of the gastrointestinal tract.
This lymphoma consists of a diffuse proliferation of small round
lymphocytes and small cleaved cells and tends to an extraintestinal
dissemination. Clinical behavior of this entity is more aggressive
than that of the same primary nodal lymphoma. We discuss the evolution
of opinions of this entity.
Gastrointestinal
involvement and multiple lymphomatous polyposis in mantle-zone
lymphoma.J
Clin Oncol. 1986 Jun;4(6):866-73.
The clinical,
histologic, and immunologic features of three cases of lymphoma
presenting with gastrointestinal symptoms and involving the
gastrointestinal tract were studied. Two of the cases had involvement
of long segments of the bowel with polypoid lesions, a rare
presentation of gastrointestinal lymphoma referred to as multiple
lymphomatous polyposis (MLP). All cases were classified as mantle-zone
lymphoma (MZL), a follicular variant of intermediate lymphocytic
lymphoma (ILL) characterized by the proliferation of small atypical
lymphoid cells as wide mantles surrounding benign-appearing germinal
centers. The patients were typical of other patients with MZL in that
they were male, middle age or older, and their clinical courses were
not aggressive despite the presence of disease at an advanced stage.
Our review of the literature suggests that there is an inordinate
number of cases of MZL with gastro-intestinal involvement. We also
note that most reports of cases of MLP have described histologic
lesions remarkably similar to what we have observed. We conclude that
MZL may have predilection for involvement of the gastro- intestinal
tract, that this involvement is often in the manner of MLP, and that
most cases of MLP probably have MZL or ILL. |
