Multiple lymphomatous
polyposis of the gastrointestinal tract.
Histopathology. 1984 Jul;8(4) :
641- 56.
Multiple
lymphomatous polyposis (MLP) is a distinctive type of primary
gastrointestinal lymphoma characterized by polypoid accumulations of
lymphoma tissue involving long segments of the gastrointestinal tract.
A study of four cases of MLP has shown a tendency for ileocaecal
involvement and extra-abdominal dissemination. The lymphoma is of
centrocytic type and exhibits a nodular pattern of variable degree.
Trapping of reactive follicle centres with replacement of their mantle
zones is characteristic. Immunohistochemical studies show a high
concentration of monotypic SIg demonstrable in both cryostat and
paraffin sections together with the other features of malignant
lymphoma, centrocytic. The histological features of MLP bear a close
resemblance to those of intermediate cell and mantle zone lymphoma, as
described by American workers, which suggests that these two
conditions and malignant lymphoma, centrocytic, are the same entity.
In the gastrointestinal tract malignant lymphoma, centrocytic,
produces a characteristic classic clinicopathological picture (MLP).
In view of its less favourable prognosis it is important to
distinguish MLP from other primary gastrointestinal lymphomas of
follicle centre cell origin.
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