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Kimura's disease occurred in the whole arm.
Joint Bone Spine. 2008 Jan;75(1):76-7. Epub 2007 Aug 28
Kimura's
disease is a rare, chronic inflammatory disease of unknown etiology.
It occurs commonly in head and neck. We present a rare case of
Kimura's disease that occurred widely in the whole arm. A
17-year-old man presented with 5 years history of palpable
non-tender mass in the antero-medial aspect of the upper arm. Blood
investigations showed a peripheral eosinophilia and the elevation of
IgE. Coronal and sagittal T1 and T2 images showed the multiple
lobulated, and well-demarcated masses in the subcutaneous layer. On
histological assessment, it was noted that within the subcutaneous
fat there was an ill-defined non-encapsulated proliferation of
lymphoid follicles with focal eosinophilic folliculolysis. The lymph
nodes showed numerous prominent lymphoid follicles with florid
germinal centers, follicular hyperplasia and massive perinodal
eosinophilic infiltration.
Kimura disease:
diagnosis and prognostic factors.
Otolaryngol Head Neck Surg. 2007;137(2):306-11.
OBJECTIVES:
To establish a preoperative diagnostic system and examine prognostic
factors for Kimura disease. STUDY DESIGN: Retrospective study.
SETTING: Hospital records were reviewed for nine cases of Kimura
disease treated in our department. Preoperative eosinophil counts
for 74 cases with untreated malignancy in the parotid gland were
also examined. RESULTS: Parotid swelling with inhomogeneities and
subcutaneous invasion on magnetic resonance imaging and eosinophils
> 10.5 percent in Asian patients clearly indicates Kimura disease.
Eosinophils > 50 percent, serum IgE levels > 10,000 IU/mL, and
multifocal lesions outside salivary glands are prognostic factors
suggesting disease recurrence. CONCLUSIONS: A preoperative decision
based on our diagnostic criteria and prognostic factors should lead
to better therapeutic outcomes for Kimura disease, for which a
definitive treatment policy has never been determined. |
