Colonic polyps in
children and adolescents.Can
J Gastroenterol. 2007 Apr;21(4):233-9.
Colonic polyps
most commonly present with rectal bleeding in children. The isolated
juvenile polyp is the most frequent kind of polyp identified in
children. 'Juvenile' refers to the histological type of polyp and not
the age of onset of the polyp. Adolescents and adults with multiple
juvenile polyps are at a significant risk of intestinal cancer. The
challenge for adult and pediatric gastroenterologists is determining
the precise risk of colorectal cancer in patients with juvenile
polyposis syndrome. Attenuated familial adenamatous polyposis (AFAP)
can occur either by a mutation at the extreme ends of the adenomatous
polyposis coli gene or by biallelic mutations in the mutY homologue (MYH)
gene. The identification of MYH-associated polyposis as an autosomal
recessive condition has important implications for screening and
management strategies. Adult and pediatric gastroenterologists need to
be aware of the underlying inheritance patterns of polyposis syndromes
so that patients and their families can be adequately evaluated and
managed. Colonic polyps, including isolated juvenile polyps, juvenile
polyposis syndrome, FAP, AFAP and MYH-associated polyposis, are
discussed in the present review.
Infectious Disease Online;
INDEX: A-D
;
INDEX: E-L
;
INDEX: M-P
;
INDEX: Q-Z
;
FUNGAL DISEASE
;
VIRAL DISEASE. |
