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Intramuscular myxoma of the face: an unusual localization. A
clinicopathological study.Dermatol
Surg. 1995 Mar;21(3):251-4.
BACKGROUND. Intramuscular myxoma is a rare benign mesenchymal lesion.
Only very rare cases of cutaneous localization of this tumor have been
described, in particular related to the somatic soft tissues of the
face. This unusual localization may clinically mimic nodular or cystic
facial lesions having different origins. OBJECTIVE. The aim of our
work was to well characterize the phenotype of the spindle cells
characteristic of intramuscular mixoma. METHODS. Tissue samples were
processed for morphological and ultrastructural studies. Moreover,
immunohistochemical stainings were performed to characterize the
expression of different nonmuscular and muscular cytoskeletal
proteins. RESULTS. The tumor was composed of sparse spindle cells
embedded in a prominent mucoid matrix. Besides the predominance of a
fibroblast-like appearance, some neoplastic cells displayed
immunohistochemical and ultrastructural features resembling either
myofibroblasts or primitive mesenchymal cells, with a modulation of
cell actin expression. CONCLUSION. The presence of multiple phenotypes
of nonmuscular, mesenchymal pathway of differentiation can be
considered a peculiar feature of intramuscular myxoma.
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February 2008
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