Hairy Cell Leukaemia is a chronic leukaemia and is characterized by cells
with fine villous surface projections and bean shaped nuclei and pale
are seen in the circulation, in the bone marrow and in the red pulp of the
The most characteristic
histological changes are observed in the Spleen.
present with splenomegaly and pancytopenia. The disease tends to follow an
In paraffin sections a
distinctive pattern of markers can be detected and these may be of
diagnostic value (specially when marrow shows a low level of
In addition to pan-B-cell
markers such as CD20 and CD79a, neoplastic cells often express CD68 (as
cytoplasmic dots) and are labelled by antibody DBA44. Acid
Phosphatase isoenzyme 5 (Tartarate - resistant) -TRAP is another useful
marker in the identification of hairy cell leukaemia.
See the images below: