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Pathology of Heterotopic Tissues in the Gallbladder

Dr Sampurna Roy  MD                       July 2014 

Syn: Ectopic and Metaplastic Tissue of the Gallbladder:

Heterotopic commonly present in the gallbladder include liver, pancreas, gastric and intestinal mucosa.

In rare cases thyroid follicle and adrenal tissue may be found in the wall of the gallbladder.

Pancreatic tissue may include islets of Langerhans, together with exocrine pancreas.

Heterotopic island of gastric mucosa together with chief and parietal cells are commonly present at the neck and fundus of the gallbladder. Macroscopically the gastric mucosa may be polypoid or plaque-like. The gastric mucosa may replace the normal mucosa or may form intramural nodule.

This well-developed foci of gastric mucosa should be distinguished from antral or gastric surface epithelium which is a metaplastic process. Metaplastic gastric mucosa is usually found in elderly patient. Enterochromaffin cells, goblet cells and paneth cells may be found in association with metaplastic antral or gastric mucosa.

Intestinal metaplasia may be present in papilloma of gallbladder. Goblet cell metaplasia and prominent hyperplasia of mucous glands are seen near carcinomas of gallbladder.

Squamous metaplasia is seen near squamous cell carcinoma, specially in Porcelain gallbladder.

Heterotopic liver should be anatomically separate from the the main organ.

Further reading:

Gastric heterotopia in the gallbladder. Case report and review of literature

Pancreatic heterotopia in the gallbladder associated with chronic cholecystitis : a rare combination

Gastric heterotopia in the gallbladder: a case report

Pancreatic heterotopia in gall bladder

Gastric heterotopia together with intestinal metaplasia in the gallbladder

Heterotopic pancreatic tissue located in the gallbladder wall

Gastric heterotopia together with squamous metaplasia in a gallbladder

Two cases of ectopic liver attached to the gallbladder wall

[Heterotopic liver tissue in the fundus of the gallbladder]

Intestinal metaplasia of the gallbladder

Metaplasia and precursor lesions of gallbladder carcinoma


Dr  Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)


Anatomy of the Gallbladder Arterial and Lymphatic Supply of the Gallbladder ;  Physiology of the Gallbladder;  Macroscopic examination and dissection of the Gallbladder Congenital Anomalies of the Gallbladder;  Double Gall Bladder (Gallbladder Duplication) Absence (Agenesis) of the Gallbladder;  "Phrygian cap" deformity of the Gallbladder Floating (Wandering) Gallbladder and Torsion of the Gallbladder;  Septation of Gallbladder Heterotopic Tissues in the Gallbladder; Acute Cholecystitis Acalculous Cholecystitis Emphysematous Cholecystitis;  Eosinophilic Cholescystitis Xanthogranulomatous Cholecystitis Chronic Cholecystitis;  Cholelithiasis;   Cholesterol stone;  Pigment stones (calcium bilirubinate) "Mixed" stones;  Melanosis of the Gallbladder;  Mucocele and Hydrops of the Gallbladder;  Cholesterolosis of the Gallbladder Porcelain Gallbladder; Gallbladder Infections;  Mucosal Hyperplasia of the Gallbladder Adenomyomatous Hyperplasia of the Gallbladder;  Polyps of the Gallbladder; Adenoma of the Gallbladder Dysplasia and Carcinoma-in-situ of the Gallbladder;  Carcinoma of the Gallbladder; Adenocarcinoma of the Gallbladder Papillary Adenocarcinoma of Gallbladder Intestinal-type Adenocarcinoma of the Gallbladder Mucinous Adenocarcinoma of the Gallbladder; Signet Ring Carcinoma of the Gallbladder; Clear Cell Adenocarcinoma of the  Gallbladder; Small (oat) cell carcinoma of the Gallbladder; Sarcomatoid Carcinoma /Carcinosarcoma of the Gallbladder;  Melanoma of the Gallbladder; Lymphoma of the Gallbladder; Undifferentiated Carcinoma of the Gallbladder Metastatic Tumours of the Gallbladder;  ;  Surgical ; ; Dermpath-India; Dermatopathology Cases; Pancreatic Pathology Online ; Gallbladder Pathology Online Paraganglioma-Online Endocrine Pathology Online  ;  Paediatric Pathology Online ; Eye Pathology Online Ear Pathology Online ; Cardiac Path Online ; Pulmonary Pathology Online Lung Tumour-Online ; Nutritional Pathology Online ; Environmental Pathology Online  ;  Soft Tissue Tumour Online-India  ;GI Path Online-India ; Case Index ; Mesothelioma-Online ; Infectious Disease Online-IndiaPathology Quiz Online .


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