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Gallbladder Pathology Online

Pathology of Heterotopic  Tissue in the Gallbladder

Dr Sampurna Roy MD


Syn: Ectopic and Metaplastic Tissue of the Gallbladder:


Heterotopic tissue commonly present in the gallbladder include liver, pancreas, gastric and intestinal mucosa.

In rare cases thyroid follicle and adrenal tissue may be found in the wall of the gallbladder.

Pancreatic tissue may include islets of Langerhans, together with exocrine pancreas.

Heterotopic island of gastric mucosa together with chief and parietal cells are commonly present at the neck and fundus of the gallbladder. Macroscopically the gastric mucosa may be polypoid or plaque-like. The gastric mucosa may replace the normal mucosa or may form intramural nodule.

This well-developed foci of gastric mucosa should be distinguished from antral or gastric surface epithelium which is a metaplastic process. Metaplastic gastric mucosa is usually found in elderly patient. Enterochromaffin cells, goblet cells and paneth cells may be found in association with metaplastic antral or gastric mucosa.

Intestinal metaplasia may be present in papilloma of gallbladder. Goblet cell metaplasia and prominent hyperplasia of mucous glands are seen near carcinomas of gallbladder.

Squamous metaplasia is seen near squamous cell carcinoma, specially in Porcelain gallbladder.

Heterotopic liver should be anatomically separate from the the main organ.


Further reading:

Gastric heterotopia in the gallbladder. Case report and review of literature

Pancreatic heterotopia in the gallbladder associated with chronic cholecystitis : a rare combination

Gastric heterotopia in the gallbladder: a case report

Pancreatic heterotopia in gall bladder

Gastric heterotopia together with intestinal metaplasia in the gallbladder

Heterotopic pancreatic tissue located in the gallbladder wall

Gastric heterotopia together with squamous metaplasia in a gallbladder

Two cases of ectopic liver attached to the gallbladder wall

[Heterotopic liver tissue in the fundus of the gallbladder]

Intestinal metaplasia of the gallbladder

Metaplasia and precursor lesions of gallbladder carcinoma




Dr  Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)









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