| Sebaceous
adenoma of oral cavity: report of case and comparative proliferation
study with sebaceous gland hyperplasia and Fordyce's granules.Oral
Dis. 2003 Nov;9(6):323-7.
Sebaceous
adenoma (SA) is a rare solitary tumour with a predilection for the
forehead and scalp. In the English literature, less than 10 cases of
SA have been described in the oral cavity. The objective of this
study was to examine the clinicopathologic features and evaluate the
expression of epidermal growth factor and its receptor, estrogen
receptor and androgen receptor in SA and in its differential
diagnoses including sebaceous gland hyperplasia (SGH) and Fordyce's
granules (FG). Additionally, we analysed the proliferative potential
of sebaceous cells from SA, SGH and FG by measuring proliferating
cell nuclear antigen (PCNA) expression and quantification of
argyrophilic nuclear organizer regions (AgNORs). The SA showed many
clinicopathologic similarities to cases previously reported
including the biphasic population of cells, in the periphery of
lobules undifferentiated basaloid cells whereas the central area was
formed by mature sebocytes. SA was composed of 198 lobules of
sebaceous cells, whereas SGH and FG showed a mean of 21 +/- 7.81 and
5.84 +/- 2.83, respectively. The AgNOR and PCNA indices were similar
in SA, SGH and FG. These data suggest that lobule counts may be used
as additional criteria in distinguishing SA of the oral cavity from
other intraoral sebaceous gland lesions.
Treatment of
Fordyce Spots With CO2 Laser. Dermatologic Surgery.Volume
29 Issue 8 Page 869-871, August 2003.
Background. Fordyce
spots are heterotopic sebaceous glands that can be located at the
lips' vermilion or the oral mucosa. Although this is considered a
rather common disorder, a treatment for this condition that
sometimes affects patients from only a cosmetic viewpoint has not
yet been described.
Objective. To
evaluate CO2 superpulsed laser treatment in two
subjects with Fordyce spots.
Methods. Two
patients with papules and yellowish plaques at the upper lip
corresponding to Fordyce spots were treated with coherent Ambulase
CO2 superpulsed laser (Coherent Medical, Palo Alto,
CA); after informed consent was obtained, two to three passes were
performed in one session using 2 and 4 W and a spot size of 2 mm.
Results. Complete
re-epithelization was observed 2 weeks later with no residual
Fordyce papules in the treated area and no side effects.
Conclusion. Our
findings suggest that CO2 superpulsed laser can be
considered a safe and effective treatment for patients with
Fordyce spots, offering excellent cosmetic results.
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