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A complex translocation
(6;12;8)(q25;q24.3;q13) in a fibrous hamartoma of infancy.Cancer
Genet Cytogenet. 2006 Dec;171(2):115-8.
We report the case of
an 18-month-old girl who came to medical attention with a left cervical
mass. Surgical excision was performed 16 months later. Histology revealed a
fibrous hamartoma of infancy. Follow-up has been uneventful, and no
recurrence of the mass has been observed. Cytogenetic analysis showed a
complex translocation involving chromosomes 6, 8, and 12, namely,
t(6;12;8)(q25;q24.3;q13). This case represents the second cytogenetic
analysis reported to date in fibrous hamartoma of infancy and reveals a
different translocation than the reciprocal translocation t(2;3)(q31;q21)
previously reported.
Spinal fibrous hamartoma of infancy: case report.
Neurosurgery. 2004 Sep;55(3):712.
OBJECTIVE AND
IMPORTANCE: Fibrous hamartoma of infancy (FHI) in the spinal cord is very
rare. It is characterized histopathologically by three elements: fibrous,
adipose, and myxoid mesenchymal tissues. CLINICAL PRESENTATION: A
10-month-old boy presented with paraparesis. Magnetic resonance imaging
showed a large intradural mass that occupied the space between the T10 and
L4 levels. INTERVENTION: We performed partial removal of the mass.
Histopathological examination of the lesion revealed that it was composed of
collagen bundles and fibrous tissue interspersed with adipose tissue,
mesenchymal tissue, and glial tissue, and it was diagnosed as FHI.
CONCLUSION: FHI in the central nervous system, especially in the spine, is
very rare, and the presence of glial tissue admixed with particular
components of FHI is quite exceptional.
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