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Cyclooxygenase-2 expression in dermatofibroma and dermatofibrosarcoma
protuberans.
J Cutan Pathol. 2008 Jan 14.
Background:
Dermatofibroma (DF) and dermatofibrosarcoma protuberans (DFSP)
occasionally resemble each other histologically but differ in
histogenesis and biological behavior. This study sought to determine
if these lesions can be differentiated by the quantity or quality of
expression of cyclooxygenase-2 (COX-2), an enzyme associated with both
reactive and neoplastic processes. Patients and methods:
Formalin-fixed and paraffin-embedded samples from 20 DFs and 20 DFSPs
were stained immunohistochemically with antibodies directed against
COX-2. Staining was evaluated semiquantitatively for percentage and
intensity using a three-tiered system. DFs were graded and analyzed by
cellularity. Findings within the tumors were compared with fibrocyte
staining in adjacent tissue. The results were analyzed. Results:
Nineteen DFs (95%) and 15 DFSPs (75%) were immunopositive for COX-2;
this difference was not statistically significant. Highly cellular DFs
showed more widespread (p = 0.0039; r = 0.614) and more intense (p =
0.0586; r = 0.429) staining than less cellular DFs and more prominent
staining in adjacent fibroblasts (p = 0.044; r = 0.608). Conclusions:
COX-2 immunostaining does not distinguish DFs from DFSPs. However, the
enzyme is expressed more widely and more intensely in more cellular,
possibly younger, DFs. The prominent expression of COX-2 in DFSP may
have clinical implications for treatment with COX-2 inhibitors in
tumors that are not amenable to surgery. |
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Dermatofibrosarcoma Protuberans
Visit:
Dermpath-India
Congenital
dermatofibrosarcoma protuberans: a case report.Actas
Dermosifiliogr. 2007 Nov;98(9):617-20.
Dermatofibrosarcoma protuberans is a rare low-grade fibrohistiocytic
tumor with onset normally at ages between 20 and 50 years. It
presents as a violaceous plaque or macule with an appearance
suggestive of vascular lesion, on which nodular lesions appear
later. Histological diagnosis is based on the presence of a
spindle-cell tumor arranged in small bundles in a characteristic
cartwheel pattern. The local recurrence rate is high but metastases
are rare. The treatment is surgical resection with wide margins. The
tumor rarely affects children under 16 years of age and it is even
less common at birth--only 27 congenital cases have been described
in the literature. We describe the case of a 10-year-old boy with
dermatofibrosarcoma protuberans present since birth and currently
without signs of recurrence.
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June 2009
Myxoid
Tumours of Soft Tissue
Classification
of Soft Tissue Tumour
Gross examination of soft tissue specimen
Lipomatous tumours |
