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Chondroid lipoma
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Soft Tissue Pathology
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| Chondroid
lipoma. Clinicopathological, immunohistochemical, and ultrastructural
analysis of six cases of a distinct entity in the spectrum of lipomas.Pathologe.
1999 Nov;20(6):330-4.
A series of six cases
of chondroid lipoma is reported in this paper. The age of the patients, four
women and two men, ranged from 34 to 75 years. Four tumours arose in the
lower and two in the upper extremities between 4.5 and 8 cm in size. Whereas
two neoplasms were located in the subcutis, four lesions were seen in
perifascial or intramuscular tissues. Histologically, all neoplasms were
encapsulated and characterized by a somewhat lobular growth pattern. The
neoplasms were composed of mature adipocytes, uni - and multivacuolated
lipoblasts, and nests and strands of cells reminiscent to hibernoma cells or
chondrocytes. Immunohistochemically and ultrastructurally the lipogenic
nature of the latter type of cells was confirmed. Interestingly, focal
immunopositivity of tumour cells for cytokeratin was found in two cases.
Tumour cells were set in a myxohyaline matrix showing different degrees of
degeneration. Chondroid lipoma represents a distinct entity in the spectrum
of lipomatous lesions and has to be distinguished from benign and malignant
neoplasms (extraskeletal chondroma, hibernoma, lipoblastoma,
chondrolipoangioma, myoepithelioma, myxoid/round cell liposarcoma, and
extraskeletal myxoid chondrosarcoma). Because they are easily misdiagnosed
as malignant tumours, familiarity with the features of chondroid lipoma is
of practical importance to avoid an overtreatment.
Cytogenetic and cytologic
features of chondroid lipoma of soft tissue.Mod
Pathol. 1999 Jan;12(1):88-91.
The cytologic and
cytogenetic findings of chondroid lipoma, a rare benign tumor of soft
tissue, have not been described. This report details the morphologic
features of a fine-needle aspiration biopsy specimen and describes a novel
cytogenetic finding. The main cytologic features consisted of clustered,
variably mature, multivacuolated, hibernoma-like cells enmeshed in a
capillary plexus, with a background of chondromyxoid material. Cytogenetic
analysis revealed a balanced translocation t (11, 16)(q13;p12-13) distinct
from the known translocation involving 16p11 in myxoid and round-cell
liposarcoma. The 11q13 breakpoint was previously noted in hibernomas,
raising the possibility of a common genetic deregulation. |
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June 2009
| Unique
cytological features and chromosome aberrations in chondroid lipoma: a
case report based on fine-needle aspiration cytology, histopathology,
electron microscopy, chromosome banding, and molecular cytogenetics.Am
J Surg Pathol. 1999 Oct;23(10): 1300-4.
Chondroid lipoma is
a rare, benign tumor that may mimic soft-tissue sarcoma clinically. Its
histopathologic features may resemble hibernoma, myxoid liposarcoma,
myxoid chondrosarcoma, and other lipomatous or chondroid neoplasms. In
this study, a chondroid lipoma was analyzed by fine-needle aspiration
cytology, histopathology, electron microscopy, chromosome banding, and
metaphase fluorescence in situ hybridization. The results demonstrate
that chondroid lipoma exhibits a characteristic pattern by fine-needle
aspiration cytology, including a mixture of benign adipose tissue with
lipoblastlike cells, and chondroblastlike cells with a fibrochondroid
matrix. Cytogenetically, a three-way rearrangement between chromosomes
1, 2, and 5 was found, together with an 11;16 translocation with a
breakpoint in 11q13, approximately 1 Mb proximal to the MEN1 region
shown to be rearranged frequently in hibernoma. The presence of a
karyotype of low complexity, but without any of the genetic aberrations
characteristic for other types of soft-tissue tumors, indicate that
chondroid lipoma develops along a unique pathogenetic pathway. |
Myxoid
Tumours of Soft Tissue
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