Large Brunner's gland adenoma: case report and literature review.World J Gastroenterol. 2006 Mar 28;12(12):1966-8.

Brunner's gland adenoma (BGA) is a very rare benign tumour of the duodenum, which is usually asymptomatic and discovered incidentally at endoscopy. Occasionally, this lesion may be large, causing upper gastrointestinal haemorrhage or intestinal obstruction. The case had a large Brunner's gland adenoma, presenting melena that was managed by endoscopic excision.

Brunner's gland adenoma: a rare cause of vomiting.Acta Paediatr. 2005 May;94(5):631-3.

Upper gastrointestinal system adenoma is generally seen amongst elderly patients and quite rarely seen during the childhood. A 14-y-old female patient was referred to our hospital with complaints of vomiting and abdominal pain. She had been followed up for 6 y with the diagnosis of familial intermittent fever and chronic renal failure due to amyloidosis. Endoscopic examination of the upper gastrointestinal system revealed mild hyperaemia in the corpus and antrum, and a polyp of 0.5x0.5 cm with an ulcerated and pedunculated top in the bulbus. Brunner's gland adenoma was diagnosed by the histopathological examination of the lesion following polypectomy. CONCLUSION: Brunner's gland adenoma is usually asymptomatic; however, it may reveal clinical findings such as obstruction, bleeding or intussusception, especially in uraemic patients. Thus, we would like to emphasize that, in patients with chronic renal failure and acute onset vomiting and abdominal pain, Brunner's gland adenoma should be considered in the differential diagnosis.

Brunner's gland adenoma: a report of two cases.J Med Assoc Thai. 2005 Jun;88(6):841-4.

Brunner 's gland adenoma is a very rare benign tumor of the duodenum. Only two cases of the adenoma have been in the file of the surgical pathology unit of Ramathibodi Hospital since 1992 and presented in this communication. The tumor is capable of producing a variety of clinical manifestations. Presently, endoscopic study plays an important role in both detection and diagnostic biopsy. Local excision, either by endoscopy or surgery is the main treatment in symptomatic cases. Ductal malignancy on top of Brunner's gland adenoma was described in one from estimated 200 recorded cases in the English literature since 1835.