|
Peritoneal metastases from an atypical fibro xanthoma.Am
J Surg Pathol. 2006 Aug;30 (8):1041-6.
Atypical fibroxanthoma (AFX)
is a mesenchymal neoplasm usually occurring in sun-exposed skin of
elderly patients. The majority have an excellent prognosis, as
recurrences are uncommon and metastases are rare. We present a case of
an 81-year-old man who developed widespread peritoneal metastases from
an AFX on his scalp, which was completely excised 3 years earlier.
Histology of the scalp lesion showed a markedly pleomorphic neoplasm
characteristic of AFX. Features associated with increased risk of
metastasis, namely lymphovascular space invasion, deep invasion, and
substantial necrosis, were not present. An extensive
immunohistochemical panel was performed. The tumor cells were negative
for melanocytic, epithelial, and smooth muscle immunohistochemical
stains, and positive for vimentin, CD10, CD99, and focally for CD68.
Histologically, the peritoneal tumor was virtually identical to the
original scalp lesion and had an identical immunohistochemical
profile. Electron microscopy of the peritoneal tumor revealed
pleomorphic undifferentiated cells with abundant lipid vacuoles. This
is the first reported case of AFX with peritoneal metastases. Although
AFXs generally have an excellent outcome, pathologists must remain
cognizant of the small but real potential for metastasis and this
needs to be conveyed in all reports.
|
Myxoid
Tumours of Soft Tissue
Classification
of Soft Tissue Tumour
Gross examination of soft tissue specimen
|
|
Atypical Fibroxanthoma
Visit:
Soft Tissue Pathology
Your Ad Here
| Clear cell
atypical fibroxanthoma - report of a case with review of the literature.J
Cutan Pathol. 2006 May;33(5):343-8.
Clear cell atypical
fibroxanthoma (CCAFX) is a rare variant of atypical fibroxanthoma (AFX), a
pleomorphic dermal tumour associated with a good prognosis. A 67-year-old
man presented with a rapidly growing nodule on the ear, which had appeared
over a 2-week period. Sections showed an ulcerated nodule composed of
pleomorphic spindled and polygonal cells with clear cytoplasm, invested by a
delicate vascular stroma, reminiscent of clear cell renal cell carcinoma.
Numerous mitotic figures were seen. The tumour cells stained with vimentin,
CD68 and CD99 and were cytokeratin-negative. The immunohistochemical and
ultrastructural features supported a diagnosis of CCAFX. The diagnosis of
CCAFX requires the exclusion of other pleomorphic clear cell tumours that
can occur in the skin by using a combination of morphology,
immunohistochemistry and electronmicroscopy. Murali R, Palfreeman S. Clear
cell atypical fibroxanthoma - report of a case with review of the
literature. |
|
|
February 2008
|
