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Melanoma simulating
atypical fibroxanthoma.
Am J Dermatopathol. 2007 Dec; 29(6):551-4
Melanoma may
present with a wide variety of clinicopathological presentations,
among those very rarely lesions imitating atypical fibroxanthoma (AFX).
While AFX usually is cured by complete excision, melanoma simulating
AFX has a much more serious prognosis, and thus is important to be
recognized correctly. The present series describes 4 cases of such
melanomas in 3 patients whose exact diagnosis was (markedly) delayed
due to unusual clinicopathological presentations including negative
immunohistochemistry for melanocytic markers (S100 protein, MelanA/MART1,
HMB45).
Atypical
fibroxanthoma of the external ear in a cardiac transplant recipient:
Case report and the causal role of the immunosuppressive.Auris
Nasus Larynx. 2007 Sep 4
therapy.
Atypical
fibroxanthoma (AF) is an unusual cutaneous fibrohistiocytic tumour
that is most commonly found in ENT sun-exposed areas of elderly males.
Cardiac transplant patients have an increased incidence of multiple
cutaneous neoplasms, but the AF is uncommon. Although this neoplasm is
benign, it may mimic spindle cell carcinoma, squamous cell carcinoma,
melanoma and soft tissue sarcoma on histologic examination.
Immunohistochemical stains for cytokeratin, alpha-1-antichymotrypsin,
S100 protein and vimentin may be helpful in differential diagnosis. AF
rarely recur or metastasize, if wide excision has been performed. We
present a case of a cardiac transplant recipient who developed, after
multiple cutaneous squamous tumours, an AF of external ear following
the prolonged immunosuppressive treatment with cyclosporin. |
