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E-book - History of
Medicine with special reference to India
Basic Pathology Blog
ANATOMY OF THE ATRIUM
ANATOMY OF THE VENTRICLE
ANATOMY OF THE CORONARY ARTERIES
AUTOPSY
EXAM. OF CORONARY ARTERIES
EXAMINATION
OF CARDIAC VALVES
CARDIAC VALVE DISEASE
MITRAL VALVE LESIONS
PULMONARY
VALVE DISEASE
TRICUSPID VALVE DISEASE
CARDIOMYOPATHY
CONGESTIVE HEART FAILURE
congenital heart disease
Nodular
fasciitis
Proliferative
fasciitis
Proliferative
myositis
Ischaemic fasciitis
Elastofibroma
Fibrous Hamartoma of Infancy
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Atypical
fibroxanthoma of the external ear in a cardiac transplant recipient:
Case report and the causal role of the immunosuppressive.Auris
Nasus Larynx. 2007 Sep 4
therapy.
Atypical
fibroxanthoma (AF) is an unusual cutaneous fibrohistiocytic tumour
that is most commonly found in ENT sun-exposed areas of elderly males.
Cardiac transplant patients have an increased incidence of multiple
cutaneous neoplasms, but the AF is uncommon. Although this neoplasm is
benign, it may mimic spindle cell carcinoma, squamous cell carcinoma,
melanoma and soft tissue sarcoma on histologic examination.
Immunohistochemical stains for cytokeratin, alpha-1-antichymotrypsin,
S100 protein and vimentin may be helpful in differential diagnosis. AF
rarely recur or metastasize, if wide excision has been performed. We
present a case of a cardiac transplant recipient who developed, after
multiple cutaneous squamous tumours, an AF of external ear following
the prolonged immunosuppressive treatment with cyclosporin. |
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Atypical Fibroxanthoma
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Soft Tissue Pathology
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Immunohistochemical staining of CD10 in atypical fibroxanthomas.J
Cutan Pathol. 2007 May;34(5):415-9.
BACKGROUND: The
histologic diagnosis of atypical fibroxanthoma (AFX) may be difficult at
times with a differential diagnosis including spindle cell/desmoplastic
melanoma and a poorly differentiated squamous cell carcinoma (SCC). While
there are immunohistochemical stains that may be used to support a diagnosis
of either melanoma or carcinoma, the diagnosis of AFX tends to be one of
exclusion. METHODS: A total of 35 cases including 16 AFXs, 10 poorly
differentiated SCCs and nine spindle cell/desmoplastic melanomas were
stained with the antibody against CD10. RESULTS: There was strong (3+)
diffuse expression of CD10 in 15/16 (94%) AFXs, weak (1+) to moderate (2+)
patchy expression of CD10 in 5/10 (50%) SCCs and weak (1+) expression of
CD10 in 3/9 (33%) spindle cell/desmoplastic melanomas. CONCLUSION: CD10
expression is helpful in distinguishing between AFXs, carcinomas and
melanomas and will be useful in a panel of antibodies when distinguishing
between these entities.
Melanoma simulating
atypical fibroxanthoma.
Am J Dermatopathol. 2007 Dec; 29(6):551-4
Melanoma may
present with a wide variety of clinicopathological presentations,
among those very rarely lesions imitating atypical fibroxanthoma (AFX).
While AFX usually is cured by complete excision, melanoma simulating
AFX has a much more serious prognosis, and thus is important to be
recognized correctly. The present series describes 4 cases of such
melanomas in 3 patients whose exact diagnosis was (markedly) delayed
due to unusual clinicopathological presentations including negative
immunohistochemistry for melanocytic markers (S100 protein, MelanA/MART1,
HMB45).
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June 2009
Angina pectoris
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