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CD117 immuno-reactivity
in atypical fibroxanthoma.Am
J Dermatopathol. 2008 Feb;30(1):34-6.
Atypical
fibroxanthoma (AFX) is a spindle cell neoplasm of the skin seen
typically on sun-damaged skin of the elderly. Though described as a
benign entity, local recurrence and distant metastasis have been
reported. This study aims to investigate the potential pathogenic role
of CD117, the c-kit receptor in AFX. CD117 was detected in 15 of the
16 cases (94%). The percentage of positive cells for CD117 expression
among all tumors was approximately 30%. CD117 proved to be a very
sensitive marker of AFX. This antibody may be a useful diagnostic
adjunct in AFX.
Recurrent and
metastasizing atypical fibroxanthoma.
HNO. 2007 Dec 19.
Atypical
fibroxanthoma is a rare skin tumor that arises particularly on
sun-exposed skin. Although it is considered to be a benign tumor,
rarely, metastases arise. The accurate classification of aggressive
processes of atypical fibroxanthoma is currently still the subject of
discussion. The case of an 81-year-old patient with relapsing atypical
fibroxanthoma of the right auricle is presented. With the second
relapse, a single metastasis in the right parotid gland was detected.
A complete tumor excision was performed, and the patient declined the
recommended postoperative radiotherapy. The patient has not show any
signs of relapse for 60 months now. Atypical fibroxanthoma and the
appropriate therapy for it are described, and the newest discoveries
regarding this disease are discussed on the basis of the current
literature.
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