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Recurrent aneurysmal fibrous histiocytoma.
J Clin Pathol. 2004 Mar;57(3):312-3.
Aneurysmal
fibrous histiocytoma is a rare variant of cutaneous fibrous
histiocytoma that results from blood vessel proliferation and
haemorrhage into a fibrous histiocytoma. The resulting lesion has a
very different clinical appearance, hence the potential confusion
with other skin lesions. This report describes the case of a 48 year
old woman with a recurrent fibrous histiocytoma with prominent
vasculature, which over a three year period recurred on two
occasions, showing more progressive features of the aneurysmal
variant. In addition, squamous lined cysts were present within this
tumour, a finding that has not been described previously. The
histological features of this rare lesion and the importance of the
differential diagnosis from other similar appearing malignant
lesions will be discussed.
Aneurysmal fibrous
histiocytoma showing transition from factor XIIIa-positive to
-negative.
J Dermatol. 2002 Nov;29(11):744-7.
A
39-year-old woman visited us because of a subcutaneous induration on
her forehead of 7 months' duration. The tumor was tender, firm, and
colored blue-black. Microscopically, the tumor was composed of
fibroblastic and histiocytic cells showing no atypicality. In some
part intra- or extracellular haemosiderin was diffusely seen. There
were some blood-filled spaces of varying size without endothelial
lining. From these findings, this case was diagnosed as aneurysmal
fibrous histiocytoma (AFH), a variant form of dermatofibroma.
Immunohistochemical analysis showed that factor XIIIa-positive
histiocytic cells were distributed in the area without haemosiderin,
but such cells were absent in the area with its deposition.
Furthermore, the cells near the blood-filled space showed transition
from factor XIIIa-positive to -negative, suggesting that the stromal
instability induced by the attenuation of factor XIII may lead the
formation of the blood-filled spaces in AFH. |
