| Cutaneous
aneurysmal fibrous histiocytoma with a t(12;19)(p12;q13) as the sole
cytogenetic anomaly.Cancer
Genet Cytogenet. 2006 Jan 15;164(2):155-8.
We report a
case of a 39-year-old woman with a recurrent aneurysmal fibrous
histiocytoma of the right lower leg. Cytogenetic analysis of the
tumor specimen disclosed a 46,XX,t(12;19)(p12;q13) karyotype.
Multicolor fluorescence in situ hybridization (M-FISH), followed by
conventional FISH analysis, confirmed the reciprocal translocation
as the sole cytogenetic anomaly, and allowed for the positioning of
chromosomes 12 and 19 breakpoints proximal to the BCL3 gene and
between ETV6 and PIK3C2G gene loci, respectively. Our case
highlights the importance of distinguishing this recurrent but
benign lesion from similarly appearing malignant skin tumors.
Cytogenetic analysis may contribute to the diagnosis of this
uncommon but distinctive clinicopathological entity.
Dermatofibroma. A
clinico-pathologic classification scheme.Pathologe.
1998 Nov;19(6):412-9.
Dermatofibroma
is a common benign fibrohistiocytic lesion which presents with a
wide variety of clinicopathologic variants. This may cause great
difficulties in delineation from a variety of benign and malignant
tumours. According to their peculiarities we differentiate: 1.
Dermatofibromas with architectural peculiarities like deep
penetrating, atrophic, giant, aneurysmal ("angiomatoid"),
haemangiopericytoma-like, palisading or ossifying variants. 2.
Dermatofibromas with cellular/stromal peculiarities like clear cell,
granular cell, myofibroblastic, sclerotic, monster cell, atypical ("pseudosarcomatous"),
elusive ("haemosiderotic"), cholesterotic, and myxoid variants. 3.
Dermatofibromas with architectural and cellular/stromal
peculiarities in homogenous arrangement like epithelioid cell,
cellular benign variants, with smooth muscle proliferation, basal
cell carcinoma-like, pseudolymphomatous, multinucleate cell
angiohistiocytoma, cellular neurothekeoma, plexiform
fibrohistiocytic tumour, plexiform xanthoma and plexiform
xanthomatous tumour. 4. Complex or composite dermatofibromas with
two or more architectural and cellular/stromal peculiarities in
inhomogenous arrangement, e.g. silhouette of an epithelioid cell
histiocytoma with plexiform fascicles of cellular neurothekeoma and
granular cell features. |